Objective: This article analyzes the challenges facing non-governmental organizations (NGOs) and presents socio-economic strategies to encourage their participation in addiction prevention. Method: Data for this research were collected using the grounded theory approach and in-depth, semi-structured interviews with 20 founders, experts, and activists from NGOs in Isfahan province. Participants were selected through a theoretical and purposive sampling method. Results: The analysis of interview transcripts, conducted through a three-stage coding process, resulted in the identification of 80 descriptive codes, 16 axial categories, and 4 core categories titled "Socio-economic Challenges" and "Socio-economic Strategies." Specifically, eight socio-economic components were identified as challenging NGOs participation in addiction prevention: lack of sustainable financial resources and dependence on government aid; challenges in attracting and retaining human capital; insufficient scientific capital and specialized skills; lack of a clear and consistent system for wages and benefits; insufficient public and government trust in NGOs; lack of government convergence and legal support for NGOs; weak inclination toward voluntary cooperation; and strict security and police monitoring and control. Furthermore, eight strategies for encouraging NGOs participation were identified: financial support and provision from the public budget; passing laws and facilitating the allocation of of non-repayable loans; providing non-cash aid; facilitating the receipt of international assistance; empowering NGOs in social policy-making; creating an environment for community and government convergence with NGOs; reflecting and publicizing the effectiveness of NGOs performance; and fostering a culture of trust in NGOs. Conclusion: In the field of addiction prevention, NGOs are no longer an accessory to the government, but a necessity whose capabilities the government must cultivate and strengthen.
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