Objective: The aim of this study was to investigate the outcome of the Matrix Model of therapy on quality of life in methamphetamine abusers. Method: In a quasi-experimental research design, 15 participants were selected as the experimental group and15 participants were selected as the control group from among the 30 individuals of methamphetamine abusers who were under medical treatment. The experimental group received 24 one-hour sessions of the Matrix Model of therapy whereas the control group did not receive any intervention. The experimental and control groups completed the World Health Organization Quality of Life Scale (WHOQOL-BREF) at the pre-test, post-test, and follow-up stages. Results: The results showed that there was a significant difference in the mean scores of quality of life between the two groups in the post-test stage while there was no such significant difference between the two groups at the follow-up stage. Conclusion: Group sessions of Matrix Model of therapy have improved the short-term quality of life in methamphetamine abusers, but not their long-term quality of life.
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