Volume 5, Issue 19 (11-2011)                   etiadpajohi 2011, 5(19): 101-115 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rahimpour M, Karami M, Jalali M R. The Effect of Central Amygdala Nitric Oxide in Expression Of Drug Seeking Behaviors. etiadpajohi. 2011; 5 (19) :101-115
URL: http://etiadpajohi.ir/article-1-349-en.html
Shahed University
Abstract:   (15561 Views)
Introduction: Previous studies shows L-arginin (nitric oxide precursor) increases conditioned place preference and drug seeking behaviors whereas LG-nitro-arginine methyl ester) L-NAME( as nitric oxide synthase inhibitor decreases this process. In this project, effects of intra-central amygdale bilateral injection of nitric oxide agents on drug-seeking behaviors including rearing, sniffing and compartment entrance were investigated. Method: animals were wistar male rats (200-250 g) which allowed to be recovered after they’re being suffered from a surgery by strereotaxis apparatus to be cannulated in coordination of central amygdale nucleus (CeA). CPP was conducted using a five-day schedule of unbiased procedure. Findings: morphine (2.5-10 mg/kg s.c) induced significant drug-seeking behaviors. Naloxone (0.1-0.4 mg/kg i.p) injection pretesting (after conditioning by morphine 7.5 mg/kg) decreased the expression of behaviors. When L-arginine (0.3-3 µgr/rat) injected intra–CeA prior to naloxone (0.4 mg/kg), increased behaviors but L-NAME (0.3-3 µgr/rat) intra–CeA injections prior to L-arginine (0.3 µgr/rat) pretesting, caused significant decreasement of L-arginine response. Conclusion: NO in the CeA may play an important role in the drug seeking behaviors induced of morphine.
Full-Text [PDF 31 kb]   (1673 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/05/18 | Accepted: 2014/05/18 | Published: 2014/05/18

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Scientific Quarterly Research on Addiction

Designed & Developed by : Yektaweb