Volume 5, Issue 19 (11-2011)                   etiadpajohi 2011, 5(19): 87-99 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hashemi M, Karami M, Zarrindast M R, Sahebgharaniraei M. The Effect of Injection of L-Arginine and L-NAME in the Rat’s Intra-Hippocampal (CA1) in Morphine-Induced Antinociception in Formalin Test. etiadpajohi. 2011; 5 (19) :87-99
URL: http://etiadpajohi.ir/article-1-348-en.html
Shahed University
Abstract:   (7359 Views)
Introduction: Intra-hippocampal CA1 injections of L-arginine, a nitric oxide precursor and NG-Nitro-L-arginine Methyl Ester (L-NAME), a nitric oxide synthase inhibitor, on morphine-induced antinociception in rat formalin test were investigated. Method: To induce inflammation pain, male Wistar rats received subcutaneous (s.c.) injections of formalin (50 μl at 2.5%) once prior to testing. Morphine (3-9 mg/kg) was injected intraperituneally (i.p.) 10 min before injection of formalin. Present study show that pre-administration (5 min) of L-arginine (0.15, 0.3, 1.0 and 3.0 µg/rat), but not L-NAME (0.15, 0.3 and 1.0 µg/rat) to the administration of formalin, during testing at the early phase reversed morphine-induced response. But at the late phase both agents' injections caused a significant effect. The response to L-arginine was blocked by L-NAME pre-administration. On the other hand, L-arginine or L-NAME by itself did induce pain behavior at the late phase. According to data interactions between morphine and L-arginine was statistically significant. Conclusion: Based on the finding, NO in the rat hippocampal CA1 area is involved in morphine-induced antinociception.
Full-Text [PDF 31 kb]   (1368 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/05/18 | Accepted: 2014/05/18 | Published: 2014/05/18

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Scientific Quarterly Research on Addiction

Designed & Developed by : Yektaweb