TY - JOUR JF - etiadpajohi JO - etiadpajohi VL - 5 IS - 19 PY - 2011 Y1 - 2011/11/01 TI - The Effect of Central Amygdala Nitric Oxide in Expression Of Drug Seeking Behaviors TT - اثر نیتریک اکساید هسته مرکزی آمیگدال در بروز رفتارهای جستجوی دارو N2 - Introduction: Previous studies shows L-arginin (nitric oxide precursor) increases conditioned place preference and drug seeking behaviors whereas LG-nitro-arginine methyl ester) L-NAME( as nitric oxide synthase inhibitor decreases this process. In this project, effects of intra-central amygdale bilateral injection of nitric oxide agents on drug-seeking behaviors including rearing, sniffing and compartment entrance were investigated. Method: animals were wistar male rats (200-250 g) which allowed to be recovered after they’re being suffered from a surgery by strereotaxis apparatus to be cannulated in coordination of central amygdale nucleus (CeA). CPP was conducted using a five-day schedule of unbiased procedure. Findings: morphine (2.5-10 mg/kg s.c) induced significant drug-seeking behaviors. Naloxone (0.1-0.4 mg/kg i.p) injection pretesting (after conditioning by morphine 7.5 mg/kg) decreased the expression of behaviors. When L-arginine (0.3-3 µgr/rat) injected intra–CeA prior to naloxone (0.4 mg/kg), increased behaviors but L-NAME (0.3-3 µgr/rat) intra–CeA injections prior to L-arginine (0.3 µgr/rat) pretesting, caused significant decreasement of L-arginine response. Conclusion: NO in the CeA may play an important role in the drug seeking behaviors induced of morphine. SP - 101 EP - 115 AU - Rahimpour, Mahnaz AU - Karami, Manijeh AU - Jalali, Mohammad Reza AD - Shahed University KW - morphine KW - nitric oxide KW - central amygdale KW - L-arginine KW - L-NAME KW - drug seeking behavior UR - http://etiadpajohi.ir/article-1-349-en.html ER -