Objective: The aim of this study was to investigate the moderating role of self-compassion in the relationship between resilience to stress and drug craving in drug-dependent men. Method: The present study was descriptive-correlational with structural equation model design. The statistical population included all drug-dependent men referred to addiction treatment centers in the city of Andisheh. Of this population, 140 people were selected by purposive sampling method and completed the post-detoxification craving and temptation scale, the resilience scale, and the self-compassion scale. Data were analyzed using Pearson's correlation coefficient, structural equation modeling, and bootstrapping method with 5000 re-samples. Results: The results of the structural equation model showed that the direct effects of the variables of resilience to stress and self-compassion on drug craving were significant. Also, the interactive effect of self-compassion and resilience variables on drug craving in drug-dependent men was statistically significant. Conclusion: According to the results, it can be said that both variables of resilience to stress and self-compassion play an important role in craving. Also, the results showed that the effects of resilience to stress in managing drug craving are moderated by self-compassion.