Objective: The aim of this study was to evaluate the effectiveness of group logo therapy on psychological hardiness and well-being in women with substance-dependent spouses. Method: The present research was quasi-experimental with pretest-posttest design with a control group. The statistical population of this study included all women with substance-dependent spouses referred to the addiction treatment clinics in Behbahan in 2019. Among them, 40 individuals were selected by convenience sampling method and randomly assigned into two experimental (n=20) and control groups (n=20). The experimental group received 10 sessions of logo therapy training, while the control group did not receive any intervention. Both groups were evaluated using the psychological well-being scale and the psychological hardiness questionnaire in both pretest and posttest. The data were analyzed using multivariate and univariate analyses of covariance. Results: The results showed that there was a significant difference between the posttest scores of the two groups. Thus, group logo therapy could increase psychological well-being and hardiness in women with substance-dependent spouses in the experimental group. Conclusion: According to the results, addiction specialists can use logo therapy to increase psychological hardiness and well-being in women with substance-dependent spouses.