Objective: The current study was an attempt to examine the role of family emotional atmosphere, perception of parenting styles, family communication patterns, and perceived social support in predicting the abuse of industrial psychoactive substances in students. Method: The statistical population of this study included all male students in Bachelor and Master's programs in Razi university of Kermanshah in the academic year of 2014-15. The number of 400 students was selected by cluster sampling. The data collection instruments consisted of Family Emotional Atmosphere Questionnaire, Perception of Parenting Styles Scale, and Family communication Patterns and Social Support Perception. discriminant analysis in simultaneous and stepwise modes was used for data analysis. Results: The results of data analysis showed that the liner combination of family emotional atmosphere, perception of parenting styles, family communication patterns and perceived social was a good predictor of the abuse of industrial psychoactive substances in students. Conclusion: The findings of this study suggest the importance of family emotional atmosphere, perception of parenting styles, family communication patterns and social support perception in substance abuse.