Objective: The present study was aimed at comparing the effectiveness of medicinal and cognitive-behavioral rehabilitation approaches in the adjustment rate of the families seeking rehabilitation. In this study, a quasi-experimental research design with pretest-posttest and control group was employed. Method: The statistical population of this study included all the patients presenting to Tehran’s rehabilitation centers in 2014. The search sample consisted of 30 participants who were selected through purposive sampling and were selectively assigned into three 10-participant groups. The two experimental groups were treated by medicinal and cognitive-behavioral rehabilitation approaches, and the control group awaited the treatment. Twelve weeks after the intervention, all the participants were evaluated through Spanier Dyadic Adjustment Scale (1976). Results: The results of the data analysis indicated that both treatment approaches were effective in the individuals’ adjustment rate (P<0.001) while cognitive-behavioral approach was more effective than the medicinal one. Conclusion: Psychological treatments are effective methods for treatment of disorders and can replace medicinal therapies.