Objective: The present study aimed at examining the mediating role of life satisfaction in determining the relationship between coping strategies for stress and attitudes towards addiction. Method: This study was a descriptive-correlational study whose statistical population included all the high school students of Abadan. Then, the number of 400 students was selected by random sampling method as the sample and they filled in attitude towards addiction scale, coping responses inventory, and life satisfaction inventory. Results: Problem-focused coping strategies could indirectly predict attitude towards addiction by means of life satisfaction. However, emotion-focused coping strategies could predict attitudes towards addiction neither directly nor indirectly. Conclusion: If adolescents are not equipped with efficient coping strategies and have low levels of life satisfaction, they will be directed into a state with positive attitude towards addiction. It is possible to prevent addiction in adolescents via teaching life skills, including efficient strategies to cope with stress and high levels of life satisfaction.
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