Aim: The aim of this study was to determine the relationship between social support and psychological hardiness with resilience in women with substance-dependent spouses under medical treatment centers in Zahedan. Method: The research method was descriptive-correlation type. Sample of the study included 200 women with drug-addicted spouses who were selected by convenience sampling method and the social support questionnaire of Wax and colleagues (1986), the psychological hardiness questionnaire of Ahvaz and colleague (1998) and the Connor and Davidson resilience questionnaire (2003). Pearson correlation coefficient and regression analysis were used to analyze the data. Results: The results showed that there is a significant positive relationship between social support and psychological hardiness with the resilience of women with drug-addicted spouses. Also, the results of regression analysis revealed that approximately 58% of the resilience variance of spouses of women with drug-addicted spouses is predictable based on social support and psychological hardiness. Conclusion: Given that social support and psychological hardiness are directly related to the resilience of women with drug-addicted spouses and can predict resilience, to increase the resilience of addicted families, the social support program of these families can be prioritized and training class used to increase their psychological hardiness.