Objective: People with heroin abuse have many problems in executive functions such as response inhibition, organization, emotional self-regulation, attention, and memory. The aim of this study was to investigate the effect of computerized cognitive rehabilitation on improving response inhibition in people with heroin abuse. Method: The present study was a quasi-experimental with pretest-posttest design with control group. The statistical population included all people with heroin abuse in Tehran. Among them, 30 people were selected through purposive sampling and were assigned into two experimental and control groups. The research instrument was the Go/no Go computer test. Captain’s Log Cognitive Rehabilitation Program was performed for 20 sessions of 50-60 minutes and twice a week for the experimental group. Results: The results of covariance analysis showed that Captain's Log cognitive rehabilitation program improved response inhibition in men with heroin abuse (p<0.001). Conclusion: The results of the present study showed that the computer cognitive rehabilitation program can be used as a suitable method to improve response inhibition in men with heroin abuse and as a result leads to quit and non-relapse of heroin use.