Objective: The aim of this study was to determine the contribution of emotional self-regulation and behavioral activation/inhibition systems in addicted patients' psychological well-being under the mediating role of thinking styles. Method: The current research employed a descriptive correlational method. Hofmann & Kashdan's Affective Styles Questionnaire, Behavioral Inhibition Activation Inventory, Sternberg & Wagner's Thinking Styles Inventory, and Psychological Well-Being Questionnaire were used for data collection. A sample of 100 addicts in Nazarbad was selected by random sampling. The collected data were analyzed using PLS Software. Results: The results showed that self-regulation has a positive effect on thinking styles and well-being; and thinking styles have a positive impact on psychological well-being. Moreover, behavioral activation/ inhibition systems have a positive effect on thinking styles and on psychological well-being. Conclusion: The role of emotional self-regulation and behavioral/inhibition activation systems with the mediation of thinking styles is predictable in addicted patients' psychological well-being.