Objective: The aim of this study was to determine the effectiveness of mindfulness-based return prevention therapy in social well-being and relapse prevention in crystal users. Method: In a quasi-experimental research design, 40 clients with a diagnosis of crystal abuse disorder (who successfully completed the detoxification period) were selected via purposive sampling and were then divided into two experimental and control groups. The experimental group received 10 group sessions of mindfulness-based therapy (one session per week), while the control group did not receive any treatment during this period. The participants responded to Keyes's Social Well-Being Scale (1998) and also took a morphine test before and after the onset of the treatment. Results: The results showed that there was a significant difference between the two groups in terms of social well-being at the post-test and follow-up stages. In addition, the results of Chi-square test indicated that there was a significant difference between the two groups in the frequency of return. Conclusion: The findings of this study showed that mindfulness-based return prevention therapy is effective in increasing social well-being and preventing relapse in crystal consumers.