Objective: The aim of this study was to examine the causal relation of self-regulation and moral intelligence with addiction potential through the mediator role of sensation seeking among female students. Method: This study falls within the category of descriptive/ structural equation modeling (correlational) research. The statistical population of this study consisted of all high school female students of Bushehr in the academic year 2016-2017. From among this population, 240 students were selected as the participants via multistage cluster sampling and responded to Addiction Potential Scale, Motivated Strategies for Learning Questionnaire, Moral Intelligence Scale, and Sensation Seeking Scale. Results: The results showed that the conceptual model of the research enjoys an acceptable fitness with the data. In this model, all direct, indirect, and general routes were obtained significant towards the prediction of addiction potential. In the same way, sensation seeking plays a mediating role in the relationship of self-regulation and moral intelligence with addiction potential. Conclusion: It can be concluded that it is essential to assign credit to psychological variables, like sensation seeking, self-regulation, and moral intelligence in adolescent drug prevention programs.