Objective: The present study aimed to examine the relationship of spiritual health and self-efficacy with addiction potential among addicts and non-addicts in Jiroft. Method: The method of the present study was correlational. The statistical population of this study included all male addicts who had referred to drug rehab centers and male non-addicts of Jiroft in 2015. From among the population, 136 addicts and 147 non-addicts were selected as the sample via simple random and convenience sampling methods, respectively. Results: The results of logistic regression analysis indicated that all the three variables of spiritual health (P<.04), self-efficacy (P<.001), and addiction potential (P<.03) could significantly discriminate the two groups from each other. Conclusion: Therefore, training spiritual health and religiosity as well as training self-efficacy to clients, especially to people with addiction potential can play a crucial role in decreasing their dependence on drugs in addition to conventional withdrawal methods.