Objective: This study was aimed at predicting tendency to drug use based on behavioral activation and inhibition systems, cognitive flexibility, and distress tolerance among students. Method: The research method used in this study was descriptive and correlational. The statistical population of this study included all high school students in Ardabil in the academic year of 2015-2016. From among the population, 255 students were chosen via cluster random sampling method as the aprticipants, but the total of 230 questionnaires was analyzed at the end. For data collection, Zargar et al.'s Addiction Potential Scale (2006), Gray-Wilson Personality Questionnaire (1989), Dennis and Vander Wal Cognitive Flexibility Questionnaire (2010), and Simons and Gaher’s Distress Tolerance Questionnaire (2005) were used. Results: The results indicated that behavioral activation system has a significant positive relationship with tendency to drug use in students. In addition, it was found that behavioral inhibition system, cognitive flexibility, and distress tolerance were significantly correlated with tendency to drug use in students. In addition, regression analysis revealed that almost 45% of the total variance in students' tendency to drug use was predicted by behavioral activation and inhibition systems, cognitive flexibility, and distress tolerance. Conclusion: It can be concluded that behavioral activation and inhibition systems, cognitive flexibility, and distress tolerance are the variables  interrelated with tendency to drug use in students. Therefore, these variables should be taken inrto account in addiction prevetion and treatment programs.